Table 1

Cytokines affecting growth and motility of lung alveolar epithelial cells

PromotersGrowthInhibitorsPromotersMigrationInhibitors
EGF/TGFα86 88 ++
Acidic FGF86 88 ++
Basic FGF86 ++
FGF-7/KGF1-150 86 88 91 ++
IL-61-151 86 88 +++
HGF86 88 ++
IL-21-152 88 135 ++
PDGF86 88 ++
TGFβ1-153 86 88 +++
IFN-γ1-154 88 135 +++
IGF-I and II88 87 ++

  • ↵1-150 KGF is pro-migratory for lung alveolar epithelial cells (LAEC) seeded on a fibronectin matrix but not on a neutral gelatin matrix.88 ,135

  • ↵1-151 IL-6 is equivocal factor of LAEC growth and migration but inhibits TGFα- and EGF-induced LAEC migration on gelatin matrix.88

  • ↵1-152 IL-2 is equivocal factor of LAEC migration but promoter when cells have been pre-exposed to IFN-γ.88

  • ↵1-153 Amongst TGFβ isoforms only TGFβ3 is pro-migratory for LAEC.88

  • ↵1-154 IFN-γ is equivocal factor of LAEC migration but inhibits TGFα- and EGF-induced LAEC migration on gelatin matrix.88