Table 1

Family studies in pulmonary function

Reference		Location and year		Study subjects		Lung function indices		Correlations		Comments
Reference		Location and year		Study subjects		Lung function indices		ρ_sp	ρ_mo	Comments		ρ_fo	ρ_sib
Tager et al 19		USA, 1976		148 households, 469 subjects		FEV₁, %	0.04	0.18^1-150	0.25^1-150	0.26^1-150	FEV₁ (%) less correlated than FEV₁ score
Tager et al 19		USA, 1976		148 households, 469 subjects		FEV₁score	0.05	0.11	0.16^1-150	0.19^1-150	FEV₁ (%) less correlated than FEV₁ score
Schillinget al 20		USA, 1977		376 families, 816 children and their parents		rFVC	0.07	0.19^1-150	0.12^1-150	0.27^1-150	Separate parent-offspring correlations; smaller ones are selected
						rFEV₁	0.07	0.17^1-150	0.11^1-150	0.21^1-150
						rVmax₅₀	0.07	0.15^1-150	0.12^1-150	0.16^1-150
Kauffmann et al 21		France, 1989		945 families, 1160 children and their parents		rFVC	0.18^1-150	0.26^1-150	0.19^1-150	0.30^1-150	Significant spousal correlations
						rFEV₁	0.20^1-150	0.26^1-150	0.15^1-150	0.34^1-150
						rFEF_25–75%	0.23^1-150	0.21^1-150	0.16^1-150	0.27^1-150
Coultas et al 22	USA, 1991	733 households, 336 spouse pairs, 1059 parent-child pairs, 412 sib pairs	rFVC rFEV₁	0.11 0.10	0.26^1-150 0.22^1-150	=ρ_mo =ρ_mo	0.37^1-150 0.24^1-150	Parent-offspring correlations: 6–17 year group
Chenet al 23-25		Canada, 1996, 1997, 1998		309 families, 1045 subjects		rFVC	0.08	0.17^1-150	0.18^1-150	0.35^1-150	First degree relative correlations were not significantly different for rFEV₁, rFEF_25–75% and rV_max50/FVC
						rFEV₁	0.04	0.11^1-150	0.18^1-150	0.11^1-150
						rFEF_25–75%	0.11	0.15^1-150	0.22^1-150	0.19^1-150
						rVmax₅₀/FVC	0.11	0.16^1-150	0.25^1-150	0.27^1-150
Givelber et al 26		USA, 1998		1408 families, 5003 adult subjects		rFEV₁	0.05	0.19^1-150	0.12^1-150	0.22^1-150	Sib-sib correlation was greater than parent-offspring correlation
Givelber et al 26		USA, 1998		1408 families, 5003 adult subjects

FEV₁ = forced expiratory volume in one second; FVC = forced vital capacity; FEF_25–75% = forced expiratory flow between 25% and 75% of the vital capacity; Vmax₅₀ = maximal expiratory flow rate at 50% of vital capacity; ρ_sp = spousal correlation; ρ_mo = mother-offspring correlation; ρ_fo = father-offspring correlation; ρ_sib = sibling-sibling correlation; r = residual.
↵1-150 p<0.05.