Association of asthma and wheeze in the previous 12 months at 26 years with early life risk factors and adult characteristics. Odds ratios are controlled for other factors in the table
| n (%) | Asthma | Wheeze | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p3-1 | OR (95% CI) | p3-1 | ||||||
| Sex | |||||||||
| M | 2892 (45.0) | 1 | 0.051 | 1 | <0.001 | ||||
| F | 3528 (55.0) | 1.21 (1.00 to 1.46) | 1.33 (1.14 to 1.55) | ||||||
| Maternal smoking in pregnancy | |||||||||
| No | 2887 (45.0) | 1 | 0.669 | 1 | 0.708 | ||||
| Stopped prior | 861 (13.4) | 1.03 (0.78 to 1.37) | 1.18 (0.94 to 1.47) | ||||||
| Stopped during | 305 (4.8) | 0.97 (0.63 to 1.50) | 0.90 (0.63 to 1.30) | ||||||
| <5/day | 453 (7.1) | 1.09 (0.77 to 1.56) | 0.87 (0.64 to 1.19) | ||||||
| 5–14/day | 1245 (19.4) | 1.04 (0.81 to 1.34) | 1.15 (0.94 to 1.40) | ||||||
| ⩾15/day | 669 (10.4) | 0.81 (0.58 to 1.14) | 0.99 (0.77 to 1.27) | ||||||
| Birth weight (kg) | |||||||||
| <2 | 66 (1.0) | 1.99 (0.96 to 4.12) | 0.004 | 1.53 (0.80 to 2.92) | 0.001 | ||||
| 2–2.5 | 263 (4.1) | 1.33 (0.86 to 2.06) | 1.02 (0.70 to 1.49) | ||||||
| 2.5–3 | 1194 (18.6) | 1.21 (0.95 to 1.55) | 1.24 (1.02 to 1.51) | ||||||
| 3–3.5 | 2505 (39.0) | 1 | 1 | ||||||
| 3.5–4 | 1818 (28.3) | 0.94 (0.74 to 1.18) | 0.92 (0.76 to 1.10) | ||||||
| >4 | 574 (8.9) | 0.81 (0.55 to 1.18) | 0.75 (0.56 to 1.02) | ||||||
| Paternal social class at birth | |||||||||
| I | 381 (5.9) | 1.60 (1.09 to 2.35) | 0.0073-2 | 0.94 (0.67 to 1.33) | 0.9793-2 | ||||
| II | 859 913.4) | 1.21 (0.91 to 1.61) | 0.93 (0.73 to 1.18) | ||||||
| III NM | 923 (14.4) | 1.12 (0.85 to 1.49) | 1.05 (0.84 to 1.31) | ||||||
| III M (baseline) | 2839 (44.2) | 1 | 1 | ||||||
| IV | 824 (12.8) | 0.93 (0.68 to 1.26) | 0.85 (0.67 to 1.07) | ||||||
| V | 272 (4.2) | 0.95 (0.58 to 1.57) | 1.16 (0.82 to 1.64) | ||||||
| Other | 322 (5.0) | 1.60 (1.11 to 2.32) | 1.13 (0.82 to 1.56) | ||||||
| Older children in house, age 5 | |||||||||
| None | 2637 (41.1) | 1 | 0.034 | 1 | 0.749 | ||||
| 1 | 2287 935.6) | 0.82 (0.65 to 1.04) | 0.96 (0.80 to 1.16) | ||||||
| 2 | 961 (15.0) | 0.67 (0.49 to 0.93) | 0.96 (0.76 to 1.22) | ||||||
| >2 | 535 (8.3) | 0.79 (0.54 to 1.16) | 0.97 (0.72 to 1.29) | ||||||
| Younger children in the house, age 5 | |||||||||
| None | 3610 (56.2) | 1 | 0.757 | 1 | 0.277 | ||||
| 1 | 2480 (38.6) | 1.02 (0.83 to 1.27) | 0.99 (0.84 to 1.18) | ||||||
| >1 | 330 (5.1) | 0.85 (0.55 to 1.33) | 0.73 (0.51 to 1.06) | ||||||
| Highest qualification at 26 | |||||||||
| None | 345 (5.4) | 0.70 (0.41 to 1.17) | 0.876 | 1.01 (0.72 to 1.43) | 0.526 | ||||
| CSE/NVQ1 | 1108 (17.3) | 1 | 1 | ||||||
| O/NVQ2 | 2682 (41.8) | 0.94 (0.72 to 1.22) | 1.04 (0.84 to 1.28) | ||||||
| A/Higher | 966 (15.0) | 1.03 (0.75 to 1.41) | 1.10 (0.85 to 1.42) | ||||||
| Degree | 1319 (20.5) | 0.89 (0.65 to 1.23) | 1.07 (0.83 to 1.40) | ||||||
| Smoking at 26 | |||||||||
| Never | 3126 (48.7) | 1 | 0.496 | 1 | <0.001 | ||||
| Ex | 1001 (15.6) | 1.17 (0.91 to 1.50) | 1.08 (0.84 to 1.28) | ||||||
| Current (<10 cigs/day) | 898 (14.0) | 0.92 (0.69 to 1.23) | 1.49 (1.19 to 1.86) | ||||||
| Current (⩾10 cigs/day) | 1395 (21.7) | 0.93 (0.73 to 1.20) | 2.35 (1.96 to 2.82) | ||||||
| Quintile of height at 26 | |||||||||
| 1 | 1357 (21.1) | 1 | 0.214 | 1 | 0.442 | ||||
| 2 | 1651 (25.7) | 1.03 (0.80 to 1.34) | 1.04 (0.84 to 1.28) | ||||||
| 3 | 1343 (20.9) | 1.03 (0.78 to 1.36) | 1.06 (0.84 to 1.32) | ||||||
| 4 | 1008 (15.7) | 0.90 (0.65 to 1.23) | 0.96 (0.75 to 1.24) | ||||||
| 5 | 1061 (16.5) | 0.85 (0.62 to 1.17) | 1.15 (0.90 to 1.47) | ||||||
| Quintile of BMI at 26 | |||||||||
| 1 | 1340 (20.9) | 1 | <0.001 | 1 | 0.001 | ||||
| 2 | 1298 (20.2) | 1.02 (0.75 to 1.38) | 1.02 (0.81 to 1.29) | ||||||
| 3 | 1241 (19.3) | 1.18 (0.88 to 1.60) | 0.94 (0.74 to 1.20) | ||||||
| 4 | 1317 (20.5) | 1.17 (0.87 to 1.58) | 1.13 (0.90 to 1.42) | ||||||
| 5 | 1224 (19.1) | 1.72 (1.29 to 2.29) | 1.44 (1.15 to 1.81) | ||||||