Inflammatory indices of eosinophil activation in sputum and blood
| Subject no. | Sputum eosinophil number (% inflammatory cells) | Sputum ECP (μg/ml) | Blood eosinophil number (% inflammatory cells) | Serum ECP (μg/ml) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 24 h after sBPT pretreated with placebo | 24 h after sBPT pretreated with salmeterol | Baseline | 24 h after sBPT pretreated with placebo | 24 h after sBPT pretreated with salmeterol | Baseline | 24 h after sBPT pretreated with placebo | 24 h after sBPT pretreated with salmeterol | Baseline | 24 h after sBPT pretreated with placebo | 24 h after sBPT pretreated with salmeterol | ||||
| 1 | 4.5 | 38.0 | 8.0 | 38 | 287 | 69 | 6.1 | 13.7 | 10.9 | 4.1 | 7.8 | 3.8 | |||
| 2 | 20.0 | 59.5 | 27.5 | 81 | 1402 | 188 | — | — | — | 5.5 | 14.1 | 3.8 | |||
| 3 | 2.3 | 30.6 | 5.3 | 30 | 584 | 475 | 5.7 | 7.3 | 11.3 | 3.5 | 8.8 | 11.7 | |||
| 4 | 35.6 | 75.0 | 54.8 | 315 | 5473 | 1784 | 13.3 | 1.2 | 0.4 | 9.8 | 4.6 | 3.1 | |||
| 5 | 2.8 | 6.0 | 1.6 | 51 | 102 | 70 | 3.4 | 6.3 | 4.9 | 6.9 | 16.6 | 7.6 | |||
| 6 | 11.0 | 5.4 | 8.7 | 91 | 190 | 112 | 9.0 | 6.7 | 8.5 | 6.2 | 5.4 | 10.0 | |||
| 7 | 4.6 | 23.7 | 30.1 | 462 | 1292 | 2398 | 6.8 | 6.8 | 8.2 | 4.0 | 3.8 | 3.2 | |||
| 8 | 17.5 | 49.7 | 63.3 | 1398 | 3060 | 8817 | 13.7 | 16.1 | 18.9 | 36.5 | 46.4 | 43.4 | |||
| 9 | 5.8 | 13.7 | 1.1 | 64 | 144 | 1087 | 2.3 | 7.0 | 3.9 | 4.0 | 13.1 | 9.1 | |||
| 10 | 17.8 | 49.9 | 12.3 | 104 | 309 | 67 | 10.3 | 12.9 | — | 6.6 | 13.0 | 53.5 | |||
| 11 | 1.0 | 27.3 | 19.1 | 87 | — | — | 8.2 | 8.8 | 5.9 | 2.8 | 3.5 | 20.5 | |||
| Median | 5.8 | 30.61-150 | 12.3§ | 8.2 | 7.0 | 8.2 | |||||||||
| Geometric mean | 116 | 5811-150 | 4101-150 | 6.0 | 9.21-150 | 9.41-150 | |||||||||
↵1-150 p<0.05 versus baseline; §p<0.05 versus placebo.
sBPT = specific bronchial provocative test; ECP = eosinophil cationic protein