Age, sex, atopic status, baseline spirometric indices and subject group
| Patient no. | Age (yr) | Sex | IgE (U/l) | RAST HDM1-151 | PC201-150(mg/ml) | FEV1 (l) (% predicted) | FVC (l) (% predicted) | EAR1-152(%) |
|---|---|---|---|---|---|---|---|---|
| Non-atopic non-asthma | ||||||||
| 1 | 21 | M | 12 | 0 | 44.2 | 5.34 (113) | 7.46 (131) | |
| 2 | 22 | M | 14 | 0 | 64 | 4.02 (92) | 5.05 (97) | |
| 3 | 22 | M | 57 | 0 | 16 | 3.89 (96) | 5.46 (115) | |
| 4 | 21 | M | 6 | 0 | 128 | 5.47 (121) | 6.44 (119) | |
| 5 | 21 | M | 7 | 0 | 55 | 4.93 (114) | 5.81 (114) | |
| Atopic non-asthma | ||||||||
| 6 | 21 | M | 222 | 2 | 21.8 | 5.35 (113) | 6.28 (113) | |
| 7 | 29 | F | 174 | 2 | 64 | 4.69 (151) | 6.26 (162) | |
| 8 | 22 | M | 137 | 3 | >128 | 4.86 (106) | 5.59 (102) | |
| 9 | 26 | M | 14 | 2 | 46 | 3.91 (96) | 5.15 (105) | |
| 10 | 21 | M | 54 | 3 | 6.4 | 5.62 (125) | 6.96 (129) | |
| 11 | 21 | M | 274 | 2 | 32 | 4.71 (107) | 6.12 (118) | |
| Allergen challenged asthma | ||||||||
| 12 | 36 | M | 27 | 3 | 0.28 | 3.05 (91) | 5.15 (126) | 30 |
| 13 | 28 | F | 266 | 5 | 0.2 | 2.38 (74) | 4.34 (108) | 37 |
| 14 | 22 | M | 121 | 4 | 0.18 | 3.24 (78) | 5.86 (119) | 21 |
| 15 | 23 | M | 159 | 5 | 5.72 | 6.59 (155) | 8.15 (160) | 50 |
| 16 | 23 | M | 291 | 4 | 12.9 | 4.29 (103) | 6.0 (121) | 48 |
| 17 | 37 | F | 153 | 2 | 0.9 | 2.48 (87) | 3.73 (104) | 38 |
| 18 | 18 | F | 297 | 6 | 3.17 | 2.73 (96) | 3.67 (114) | 41 |
| 19 | 21 | M | 152 | 3 | 0.8 | 4.79 (108) | 6.59 (128) | 21 |
| 20 | 21 | F | 1556 | 6 | 0.45 | 3.41 (99) | 4.53 (99) | 52 |
| 21 | 19 | M | 163 | 4 | 8.4 | 5.3 (128) | 5.8 (117) | 23 |
| 22 | 22 | M | 802 | 5 | 3.9 | 4.54 (103) | 5.23 (99) | 21 |
| 23 | 26 | M | 161 | 4 | 3 | 4.06 (104) | 5.78 (124) | 41 |
| Unchallenged asthma | ||||||||
| 24 | 19 | M | 1256 | 6 | 0.5 | 3.95 (91) | 5.25 (102) | |
| 25 | 25 | M | 15 | 3 | 7.8 | 4.67 (107) | 6.9 (132) | |
| 18 | 18 | F | 297 | 6 | 2.9 | 2.62 (96) | 5.7 (115) | |
| 19 | 21 | M | 152 | 3 | 1.0 | 4.08 (92) | 6.18 (120) | |
| 23 | 26 | M | 161 | 4 | 3.4 | 3.82 (96) | 4.3 (94) | |
Three asthmatic subjects (nos 18, 19, 23) were studied on two separate occasions (post challenge and unchallenged).
↵1-150 Concentration of methacholine (PC20) causing a 20% fall in FEV1.
↵1-151 Radioallergosorbent test to house dust mite (RAST HDM) is given as 0–6 (0 = negative, 6 = strongly positive).
↵1-152 EAR is the maximal recorded fall in FEV1 in the first hour after allergen challenge on the day of bronchoscopy.