Candidate genes for asthma and related phenotypes
| Chromosome | Candidate gene | Association | Known polymorphisms | Reference |
|---|---|---|---|---|
| 5 | IL-4 | IgE | -590 C-T | 21 |
| IL-9 | IgE | M99T | 22 | |
| β2AR | IgE, BHR, treatment response, nocturnal asthma | Codon 16, 27 | 23–29 | |
| 6 | HLA | Specific IgE | DR alleles | 30 |
| TNFα | ?Asthma | -308 | 20, 31 | |
| 10 | 5-LO | Asthma | Promoter alleles 1–5 | 32 |
| 11 | CC16 | Asthma | ? | 33 |
| FcεR1β | Atopy, IgE, BHR | Codon 181, 183, 237 | 34, 35 | |
| 14 | TCRα | Specific IgE | ? | 36 |
| 16 | IL-4α | Atopy | 576 R | 37, 39 |