Table 1

Characteristics of study subjects

Pathological diagnosis	ARDS aetiology	Mechanical ventilation (days)	Tissue source
ARDS: early stage (ARDS (E))
Exudative DAD	Neurogenic pulmonary oedema/hypotension	1	Necropsy
Exudative DAD	Sepsis	3	Necropsy
Exudative DAD	Sepsis/aspiration	4	Necropsy
Exudative DAD	Sepsis/hypotension	6	Necropsy
Exudative DAD	Pneumonia	7	Necropsy
Exudative DAD	Pneumonia	7	Necropsy
ARDS: reparative stage (ARDS (R))
Mixed/organising DAD	Pneumonia suspected	2	Open lung biopsy
Mixed/organising DAD	Shock/cardiopulmonary bypass	4	Necropsy
Mixed/organising DAD	Pneumonia	5	Open lung biopsy
Mixed/organising DAD	Miscellaneous	9	Necropsy
Mixed/organising DAD	Pneumonia	9	Necropsy
Mixed/organising DAD	Sepsis	34	Necropsy
Fibroproliferative DAD	Pneumonia suspected	12	Open lung biopsy
Fibroproliferative DAD	Pneumonia/aspiration	15	Necropsy
Fibroproliferative DAD	Hypotension/sepsis	15	Necropsy
Fibroproliferative DAD	Sepsis	23	Necropsy
Fibroproliferative DAD	Heat stroke/hypotension	30	Necropsy
Normal tissue
Normal	N/A	N/A	Surgical specimen
Normal	N/A	N/A	Necropsy
Normal	N/A	N/A	Necropsy
Fibrotic lung tissue
IPF	N/A	N/A	Open lung biopsy
IPF	N/A	N/A	Lung removed for transplant
IPF	N/A	N/A	Lung removed for transplant
IPF	N/A	N/A	Lung removed for transplant

DAD = diffuse alveolar damage; IPF = idiopathic pulmonary fibrosis (all samples demonstrated end stage lung disease); mechanical ventilation = days on mechanical ventilation before lung tissue obtained; N/A = not applicable.