Patient no. | Phase 1: log PC20 | Patient no. | Phase 2: log PC20 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Histamine | AMP | Histamine | AMP | ||||||||
Saline | l-NAME 54 mg | Saline | l-NAME 54 mg | Saline | l-NAME 170 mg | Saline | l-NAME 170 mg | ||||
14-150 | 0.24 | −0.49 | 1.65 | 2.15 | 14-150 | 0.24 | −0.19 | 1.75 | 1.50 | ||
24-150 | 0.39 | 0.22 | 1.95 | 1.47 | 24-150 | 0.46 | 0.21 | 0.99 | 0.42 | ||
34-150 | −0.09 | 0.63 | 0.69 | 1.20 | 34-150 | −0.11 | −0.50 | 1.03 | 0.87 | ||
44-150 | −0.06 | 0.06 | 1.93 | 2.44 | 44-150 | 0.42 | 0.31 | — | — | ||
54-150 | 0.01 | −0.82 | 1.22 | 1.24 | 54-150 | 0.22 | −0.35 | — | — | ||
6 | −0.11 | −0.77 | 0.55 | 0.27 | 6 | 0.61 | 0.16 | 2.02 | 2.08 | ||
7 | −0.22 | −0.27 | 1.41 | 1.54 | 7 | −0.15 | −0.93 | 0.74 | 0.33 | ||
8 | −0.78 | −0.37 | 0.25 | 0.46 | 8 | 0.00 | −0.16 | 1.29 | 0.89 | ||
9 | −0.05 | −0.34 | 1.47 | 0.98 | 9 | 0.30 | −0.09 | 1.53 | 0.95 | ||
104-150 | 0.36 | 0.11 | 104-150 | 0.61 | 0.22 | 1.07 | 1.00 | ||||
114-150 | −0.84 | −0.17 | 114-150 | 0.10 | −0.12 | 2.24 | 2.05 | ||||
124-150 | 0.45 | 0.02 | 124-150 | 0.29 | 0.43 | 1.70 | 1.07 | ||||
13 | 0.09 | −0.22 | 13 | 0.87 | 0.62 | ||||||
14 | −0.53 | −0.54 | |||||||||
15 | −0.24 | −0.50 | |||||||||
Mean | −0.09 | −0.23 | 1.24 | 1.31 | 0.25 | −0.084-151 | 1.39 | 1.074-151 | |||
95% CI | −0.31 to 0.12 | −0.45 to −0.02 | 0.77 to 1.70 | 0.76 to 1.80 | 0.09 to 0.41 | −0.33 to 0.16 | 1.05 to 1.72 | 0.68 to 1.46 |