Diagnostic criteria for diffuse panbronchiolitis
| Symptoms |
|---|
| Cough |
| Sputum production |
| Dyspnoea on exertion |
| Signs |
| Wheezing |
| Crackles |
| Radiology |
| Diffusely disseminated fine nodular shadow |
| Lower zone distribution |
| Hyperinflation |
| Lung function parameters |
| FEV1 <70% predicted or FEV1/FVC <70% |
| VC <80% predicted |
| RV >150% predicted |
| Pao 2 <80 mm Hg (∼10.6 kPa) |
| Additional “characteristic but non-diagnostic” features |
| Chronic paranasal sinusitis |
| Increased serum cold haemagglutinin without raised anti-Mycoplasma pneumoniae antibody |
| Increased serum IgA and IgG |
| Increased CD4/CD8 lymphocyte ratio |
| Proof of HLA Bw54 antigen |
| Positive rheumatoid factor |
FEV1=forced expiratory volume in one second; FVC=forced vital capacity; VC=vital capacity; RV=residual volume; Pao2 =arterial oxygen tension.