Clinical markers of disease severity split by TNF-α genotype
| TNF1 (n=33) | TNF1/TNF2 (n=20) | Mean difference | 95% CI | p value | |
|---|---|---|---|---|---|
| Mean FEV1 (% predicted) | 87.8 | 76.2 | 11.6 | 1.7 to 21.5 | 0.02 |
| Mean weight z score | −0.37 | −0.96 | 0.59 | 0.06 to 1.12 | 0.03 |
| Mean Chrispin-Norman chest radiographic score | 12.1 | 14.5 | 2.4 | −5.9 to 1.1 | 0.17 |
| Mean Shwachman score | 82.0 | 78.2 | 3.8 | −1.7 to 9.4 | 0.17 |
| No. positive for P aeruginosa | 10 | 7 | 0.72 | ||
| No. ΔF508 homozygous | 22 | 14 | 0.80 |
FEV1 = forced expiratory volume in one second.