Studies comparing PET and CT in mediastinal staging of lung cancer
| Reference | No. of patients | Nodal status (malignant/benign) (numbers indicative of) | Sensitivity PET | Specificity PET | Specificity CT (size criteria) | Specificity CT | Statistical difference PET vs CT |
|---|---|---|---|---|---|---|---|
| Chin (1995)31 | 30 (N0-N2 only) | 9/21 (patients) | 78% | 81% | 56% (1.5 cm) | 86% | Not done |
| Patz (1995)32 | 42 | 23/39 (stations) | 83% | 82% | 43% (1.0 cm) | 85% | p<0.01 |
| Sasaki (1996)33 | 29 | 17/54 (stations) | 76% | 98% | 65 % (1.0 cm) | 87% | p<0.05 |
| Sazon (1996)34 | 32 | 16/16 (patients) | 100% | 100% | 81% (1.0 cm) | 56% | p<0.01 |
| Scott (1996)35 | 62 | 10/65 (stations) | 100% | 98% | 60% (1.0 cm) | 93% | p=0.031 |
| Steinert (1997)36 | 47 | 58/133 (stations) | 93% | 99% | 72% (0.7–1.1 cm) | 94% | p=0.013 |
| Valk (1995)37 | 74 | 24/52 (sides) | 83% | 94% | 63% (1.0 cm) | 73% | p<0.01 |
| Wahl (1994)38 | 23 | 11/16 (sides) | 82% | 81% | 64% (1.0 cm) | 44% | p<0.05 |
| Totals | 339 | Weighted averages | 88% | 93% | 63% | 80% |