Mean (SD) treatment effects in 48 patients with AHI >15
| Baseline | Placebo | CPAP | p value | |
|---|---|---|---|---|
| Sleepiness | ||||
| Mean sleep onset latency (min) | Not performed | 6.2 (3.8) | 7.9 (3.8) | <0.001 |
| Epworth sleepiness score1-150 | 12 (4) | 12 (4) | 6 (3) | 0.001 |
| UMACL Energetic arousal | 20 (6) | 20 (5) | 23 (5) | <0.001 |
| Symptoms | ||||
| Symptom total1-151 | 5.0 (1.3) | 4.0 (1.3) | 2.3 (1.5) | <0.0001 |
| Cognitive performance | ||||
| SteerClear (obstacles hit)1-151 | 100 (49) | 73 (34) | 67 (26) | 0.03 |
| TrailMaking B (s)1-151 | 79 (35) | 70 (30) | 67 (29) | NS |
| Digit symbol substitution | 48 (11) | 52 (12) | 53 (12) | NS |
| Block design1-151 | 29 (9) | 32 (9) | 34 (8) | 0.02 |
| Performance IQ decrement | 10 (11) | 5 (11) | 2 (11) | 0.01 |
| RVIP (correct) | 29 (12) | 37 (14) | 36 (15) | NS |
| 8-choice reaction time (ms) | 356 (51) | 343 (40) | 345 (44) | NS |
| 2 second PASAT | 33 (9) | 37 (10) | 39 (11) | 0.001 |
| Verbal fluency (total) | 38 (11) | 41 (11) | 40 (12) | NS |
| BVRT (correct)1-151 | 7.3 (2.1) | 7.6 (1.4) | 7.7 (1.6) | NS |
| Psychological well being | ||||
| HADS anxiety1-151 | 7.9 (4.1) | 6.4 (4.4) | 5.9 (3.7) | NS |
| HADS depression1-151 | 6.3 (4.1) | 4.8 (4.0) | 3.8 (3.3) | 0.02 |
| GHQ-281-151 | 7.3 (6.7) | 4.4 (5.5) | 3.6 (5.1) | NS |
| NHP Pt 21-151 | 9.3 (0.7) | 7.2 (0.8) | 5.6 (0.8) | NS |
p values refer to comparison of placebo with CPAP.
↵1-150 First assessments compared with Hills and Armitage.10
↵1-151 Mann-Whitney test.
UMACL = UWIST mood adjective checklist; RVIP = Rapid visual information processing; PASAT = Paced auditory serial addition test; BVRT = Benton visual retention test; HADS = Hospital anxiety and depression scale; GHQ-28 = General health questionnaire-28; NHP = Nottingham health profile; NS = non-significant.