RT Journal Article
SR Electronic
T1 Reference percentiles of FEV1 for the Canadian cystic fibrosis population: comparisons across time and countries
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP thoraxjnl-2017-210899
DO 10.1136/thoraxjnl-2017-210899
A1 Sang-Ook Kim
A1 Mary Corey
A1 Anne L Stephenson
A1 Lisa J Strug
YR 2018
UL http://thorax.bmj.com/content/early/2018/02/05/thoraxjnl-2017-210899.abstract
AB Background Forced expiratory volume in 1 s (FEV1) indicates lung health in cystic fibrosis (CF). FEV1 is commonly communicated as a per cent predicted of a healthy individual sharing the same age, sex, race and height. CF-specific reference equations are complementary and calibrate a patient’s FEV1 to that of their CF peers.Objectives (1) To derive Canadian CF-specific FEV1 reference percentiles (FEV1%iles), (2) characterize how they have changed over time and (3) compare the Canadian FEV1%iles to those for USA and European CF populations.Method CF FEV1%iles are calculated using the Canadian CF Registry and quantile regression.Results The Canadian FEV1%iles demonstrated better lung function in more recent time periods within Canada, especially below the 50% percentile and in males. When compared to USA and European FEV1%iles for the same time period, Canadian FEV1%iles were higher.Conclusion CF-specific FEV1%iles can provide useful information about changes in lung health. An online calculator (available at cfpercentile.research.sickkids.ca) makes these FEV1%iles accessible.