%0 Journal Article %A Andrea Gimenez %A Karin Storrer %A Lilian Kuranishi %A Maria Raquel Soares %A Rimarcs Gomes Ferreira %A Carlos A C Pereira %T Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis %D 2017 %R 10.1136/thoraxjnl-2017-210035 %J Thorax %P thoraxjnl-2017-210035 %X The predictive value of the decline in FVC by ≥10% on survival in patients with fibrotic hypersensitivity pneumonitis is unknown. Of 112 patients included, 66 (59%) had surgical lung biopsies. Patients with ≥10% decline in predicted FVC after 6–12 months had a significantly increased risk of all-cause mortality (median survival 53 months, 95% CI 37 to 69 vs 139 months, 95% CI 66 to 212 months, p=0.007). On multivariate analysis remained associated with increasing mortality: decline in FVC by ≥10% (HR 4.13, 95% CI 1.96 to 8.70, p=0.005), lower FVC% (HR 1.03 , 95% CI 1.01 to 1.05 , p=0.003) and with decreasing mortality improvement with antigen avoidance (HR 0.18, 95% CI 0.04 to 0.77, p=0.021). %U https://thorax.bmj.com/content/thoraxjnl/early/2017/09/07/thoraxjnl-2017-210035.full.pdf