RT Journal Article
SR Electronic
T1 The quantitative link of lung clearance index to bronchial segments affected by bronchiectasis
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP thoraxjnl-2017-210496
DO 10.1136/thoraxjnl-2017-210496
A1 Sylvia Verbanck
A1 Gregory G King
A1 Wenxiao Zhou
A1 Anne Miller
A1 Cindy Thamrin
A1 Daniel Schuermans
A1 Bart Ilsen
A1 Caroline W Ernst
A1 Johan de Mey
A1 Walter Vincken
A1 Eef Vanderhelst
YR 2017
UL http://thorax.bmj.com/content/early/2017/09/02/thoraxjnl-2017-210496.abstract
AB In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease.