TY - JOUR T1 - Impact of low-dose CT screening on smoking cessation among high-risk participants in the UK Lung Cancer Screening Trial JF - Thorax JO - Thorax DO - 10.1136/thoraxjnl-2016-209690 SP - thoraxjnl-2016-209690 AU - Kate Brain AU - Ben Carter AU - Kate J Lifford AU - Olivia Burke AU - Anand Devaraj AU - David R Baldwin AU - Stephen Duffy AU - John K Field Y1 - 2017/07/07 UR - http://thorax.bmj.com/content/early/2017/07/14/thoraxjnl-2016-209690.abstract N2 - Background Smoking cessation was examined among a subset of current smokers who were high-risk participants in the UK Lung Cancer Screening (UKLS) pilot trial of low-dose CT screening.Methods High-risk individuals aged 50–75 years who completed baseline questionnaires were randomised to CT screening (intervention) or usual care (no screening control). Smoking habit was determined at baseline using self-report. Smokers were asked whether they had quit smoking since joining UKLS at short-term follow-up (2 weeks after baseline scan results or control assignment) and longer-term follow-up (up to 2 years after recruitment). Intention to treat (ITT) regression analyses were undertaken, adjusting for baseline lung cancer distress, trial site and sociodemographic variables.Results Of a total of 4055 individuals randomised to CT screening or control, 1546 were baseline smokers (787 control, 759 intervention). Smoking cessation rates were 5% (control n=36/786) versus 10% (intervention n=75/758) at 2 weeks and 10% (control n=79/775) versus 15% (intervention n=115/749) at up to 2 years follow-up. ITT analyses indicated that the odds of quitting among screened participants were significantly higher in the short term (adjusted OR (aOR) 2.38, 95% CI 1.56 to 3.64, p<0.001) and longer term (aOR 1.60, 95% CI 1.17 to 2.18, p=0.003) compared with control. Intervention participants who needed additional clinical investigation were more likely to quit in the longer term than the control group (aOR 2.29, 95% CI 1.62 to 3.22, p=0.007) and those receiving a negative result (aOR 2.43, 95% CI 1.54 to 3.84, p<0.001).Conclusion CT lung cancer screening for high-risk participants offers a teachable moment for smoking cessation, especially among those who receive a positive scan result. Further behavioural research is needed to evaluate optimal strategies for integrating smoking cessation intervention with stratified lung cancer screening. ER -