TY - JOUR T1 - Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI JF - Thorax JO - Thorax SP - 760 LP - 762 DO - 10.1136/thoraxjnl-2016-208948 VL - 72 IS - 8 AU - Helen Marshall AU - Alex Horsley AU - Chris J Taylor AU - Laurie Smith AU - David Hughes AU - Felix C Horn AU - Andrew J Swift AU - Juan Parra-Robles AU - Paul J Hughes AU - Graham Norquay AU - Neil J Stewart AU - Guilhem J Collier AU - Dawn Teare AU - Steve Cunningham AU - Ina Aldag AU - Jim M Wild Y1 - 2017/08/01 UR - http://thorax.bmj.com/content/72/8/760.abstract N2 - Hyperpolarised 3He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6–16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>−1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure–function relationships. ER -