PT - JOURNAL ARTICLE AU - Zhen Li AU - Marta Rava AU - Annabelle Bédard AU - Orianne Dumas AU - Judith Garcia-Aymerich AU - Bénédicte Leynaert AU - Christophe Pison AU - Nicole Le Moual AU - Isabelle Romieu AU - Valérie Siroux AU - Carlos A Camargo, Jr AU - Rachel Nadif AU - Raphaëlle Varraso TI - Cured meat intake is associated with worsening asthma symptoms AID - 10.1136/thoraxjnl-2016-208375 DP - 2017 Mar 01 TA - Thorax PG - 206--212 VI - 72 IP - 3 4099 - http://thorax.bmj.com/content/72/3/206.short 4100 - http://thorax.bmj.com/content/72/3/206.full SO - Thorax2017 Mar 01; 72 AB - Background Cured meat intake—a recent carcinogenic factor—may increase the risk of COPD, but its association with asthma remains unknown. Though body mass index (BMI) is a likely risk factor for asthma, its role in the diet–asthma association as a mediator has never been studied. We investigated the association between cured meat intake and worsening asthma symptoms in adults, and the role of BMI as a potential mediator.Methods Using data from the French prospective EGEA study (baseline: 2003–2007; follow-up: 2011–2013), we applied a mediation analysis in the counterfactual framework, a marginal structural model (MSM), to estimate the direct effect of baseline cured meat intake (<1, 1–3.9, ≥4 servings/week) on change in asthma symptom score (worsening or not), and the indirect effect mediated by BMI.Results Among the 971 participants (mean age 43 years; 49% men; 42% with asthma), 20% reported worsening asthma symptoms during the mean follow-up time of 7 years. Using the MSM, we reported a positive direct effect of cured meat intake on worsening asthma symptoms (multivariable OR=1.76, 95% CI 1.01 to 3.06 for ≥4 vs <1 serving/week). We also reported an indirect effect mediated by BMI (OR=1.07; 95% CI 1.01 to 1.14), accounting for 14% of the total effect.Conclusions Higher cured meat intake was associated with worsening asthma symptoms over time, through a direct effect and to a lesser extent an effect mediated by BMI. This research extends the effect of diet on asthma in adults.