TY - JOUR T1 - Absence of C/EBPα may cause bronchial smooth muscle proliferation in asthma JF - Thorax JO - Thorax SP - 281 LP - 281 DO - 10.1136/thx.2004.la0141 VL - 60 IS - 4 AU - N M Rahman Y1 - 2005/04/01 UR - http://thorax.bmj.com/content/60/4/281.abstract N2 - ▴ Roth M, Johnson PRA, Borger P, et al. Dysfunctional interaction of C/EBPα and the glucocorticoid receptor in asthmatic bronchial smooth muscle cells. N Engl J Med2004;351:560–74OpenUrlCrossRefPubMedWeb of Science Proliferation of bronchial smooth muscle (BSM) cells occurs in the airways of asthmatic patients. Glucocorticoids exert antiproliferative effects via CCAAT/enhancer binding protein α (C/EBPα), an antiproliferative transcription factor. This paper studies signalling pathways in BSM cell proliferation from 20 asthmatic and 26 non-asthmatic subjects (lung cancer/CF/emphysema). A series of elegant … ER -