TY - JOUR T1 - Effect of danazol on the biochemical abnormality of inherited antithrombin III deficiency. JF - Thorax JO - Thorax SP - 646 LP - 650 DO - 10.1136/thx.40.9.646 VL - 40 IS - 9 AU - A J Fairfax AU - R M Ibbotson Y1 - 1985/09/01 UR - http://thorax.bmj.com/content/40/9/646.abstract N2 - Seven members of a family affected by hereditary antithrombin III deficiency were identified. The disorder was associated with recurrent spontaneous episodes of phlebitis, deep venous thrombosis, and pulmonary embolism in middle age. Danazol, a 17-alkyl derivative of ethinyl testosterone, which has been used to treat other antiprotease deficiency states, was assessed in the management of two men with antithrombin deficiency. In a dose of 600 mg a day danazol appeared to correct the antithrombin deficiency. This drug may provide a useful adjunct to anticoagulant treatment, particularly before surgery. ER -