RT Journal Article
SR Electronic
T1 Acute pulmonary reaction to nitrofurantoin
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 599
OP 602
DO 10.1136/thx.29.5.599
VO 29
IS 5
A1 R. F. Pinerua
A1 B. J. S. Hartnett
YR 1974
UL http://thorax.bmj.com/content/29/5/599.abstract
AB Pinerua, R. F. and Hartnett, B. J. S. (1974).Thorax, 29, 599-602. Acute pulmonary reaction to nitrofurantoin. Acute pulmonary reaction to nitrofurantoin is a rare complication of a commonly used drug. This report of such a reaction presents studies of pulmonary function more detailed than are so far available. Studies made nine days after the drug had been withdrawn showed arterial hypoxaemia and abnormalities in ventilation-perfusion relationships. Challenge with 200 mg nitrofurantoin produced increased minute ventilation, hypoxaemia, hypocapnia, deterioration in ventilation-perfusion relationships, marked veno-arterial shunting, and a fall in steady-state transfer factor for carbon monoxide and fractional carbon monoxide uptake. Spirometry and lung volume measurements indicated a restrictive lung abnormality without effect on large airways which persisted for at least nine weeks. Three years later there had been complete resolution of the process, apart from some persistent reduction in transfer factor, possibly related to the patient's smoking habits.