TY - JOUR T1 - `Metered' aerosols of bronchodilator drugs in clinical trials JF - Thorax JO - Thorax SP - 316 LP - 318 DO - 10.1136/thx.26.3.316 VL - 26 IS - 3 AU - Burton M. Cohen Y1 - 1971/05/01 UR - http://thorax.bmj.com/content/26/3/316.abstract N2 - Airway resistance, the volume of thoracic gas, and specific airway resistance were determined before and after administration of an isoproterenol-phenylephrine mist in random fashion to 20 patients with obstructive ventilatory disorders from a hand-triggered apparatus either used by the patient or given by the physician, and from a nebulizer automatically activated by patient inspiration. Specific airway resistance changes were the most sensitive guide to broncholytic effects. Maximal change followed exposure to the breath-activated unit, suggesting that its use in similar drug trials may reduce an important source of error in estimates of the efficacy of bronchopulmonary aerosols. ER -