Calculation of unconditional and conditional reference intervals for foetal size and growth from longitudinal measurements

Stat Med. 1995 Jul 15;14(13):1417-36. doi: 10.1002/sim.4780141303.

Abstract

Methods for estimating unconditional and conditional reference intervals for foetal size and growth based on longitudinal observations are presented. The methods are based on simple random-effects regression models and involve transforming both the response and the covariate (timepoint). A dataset from a designed longitudinal study of foetal size is analysed in detail as a motivating example.

MeSH terms

  • Anthropometry
  • Data Interpretation, Statistical*
  • Embryonic and Fetal Development*
  • Female
  • Gestational Age
  • Humans
  • Longitudinal Studies
  • Models, Statistical*
  • Multivariate Analysis
  • Pregnancy
  • Reference Values
  • Regression Analysis
  • Research Design
  • Ultrasonography, Prenatal