Human mast cell proteases and mast cell heterogeneity

Curr Opin Immunol. 1989 Apr;1(4):637-42. doi: 10.1016/0952-7915(89)90033-2.

Abstract

Mast cell neutral proteases are distinctive markers of the MC(T) and MC(TC) cells in humans. Measurements of tryptase levels in vivo serve as an overall indicator of mast cell activity. Further research is needed to evaluate the functional role of these proteases as well as each mast cell type in situations related to both health and disease.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Carboxypeptidases / metabolism
  • Chymases
  • Humans
  • Mast Cells / cytology
  • Mast Cells / enzymology*
  • Peptide Hydrolases / metabolism*
  • Serine Endopeptidases / metabolism

Substances

  • Biomarkers
  • Carboxypeptidases
  • Peptide Hydrolases
  • tosylarginine methyl ester hydrolase
  • Serine Endopeptidases
  • Chymases