Sensory neuropeptides are involved in cigarette smoke induced airway hyperreactivity in guinea-pig

L Daffonchio; A Hernandez; C Omini

doi:10.1007/978-3-0348-7379-6_27

Sensory neuropeptides are involved in cigarette smoke induced airway hyperreactivity in guinea-pig

Agents Actions Suppl. 1990:31:215-22. doi: 10.1007/978-3-0348-7379-6_27.

Authors

L Daffonchio¹, A Hernandez, C Omini

Affiliation

¹ Institute of Pharmacological Sciences, University of Milan, Italy.

PMID: 2080752
DOI: 10.1007/978-3-0348-7379-6_27

Abstract

Acute cigarette smoke exposure in anaesthetized guinea-pigs resulted in non-specific airway hyperreactivity associated with inflammatory cell influx within the lung. Sensory neuropeptides seem to be involved in the genesis of smoke induced airway hyperreactivity.

MeSH terms

Acetylcholine / pharmacology
Animals
Bronchoconstriction
Capsaicin / pharmacology
Dose-Response Relationship, Drug
Guinea Pigs
Histamine / pharmacology
Hydrocortisone / pharmacology
Male
Neuropeptides / physiology*
Nicotiana*
Plants, Toxic*
Respiratory Hypersensitivity / etiology*
Sensation / physiology*
Smoke / adverse effects*
Vagotomy

Substances

Neuropeptides
Smoke
Histamine
Acetylcholine
Capsaicin
Hydrocortisone