Abstract
Surveillance of amantadine and oseltamivir resistance among influenza viruses was begun in Hong Kong in 2006. In 2008, while both A/Brisbane/59/2007-like and A/Hong Kong/2652/2006-like viruses (H1N1) were cocirculating, we detected amantadine and oseltamivir resistance among A/Hong Kong/2652/2006-like viruses (H1N1), caused by genetic reassortment or spontaneous mutation.
MeSH terms
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Amantadine / pharmacology*
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Antiviral Agents / pharmacology*
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Cell Line
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Drug Resistance, Viral / genetics*
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Hemagglutinin Glycoproteins, Influenza Virus / genetics
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Hong Kong
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Humans
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Influenza A Virus, H1N1 Subtype / classification
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Influenza A Virus, H1N1 Subtype / drug effects*
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Influenza A Virus, H1N1 Subtype / genetics
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Influenza A Virus, H1N1 Subtype / isolation & purification
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Influenza, Human / virology*
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Oseltamivir / pharmacology*
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Phylogeny
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Polymerase Chain Reaction / methods
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Population Surveillance
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Sequence Analysis, DNA
Substances
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Antiviral Agents
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Hemagglutinin Glycoproteins, Influenza Virus
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Oseltamivir
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Amantadine