The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia

Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):979-83. doi: 10.1016/j.ajog.2005.06.041.

Abstract

Objective: The purpose of this study was to compare adipokines' levels between women with and without preeclampsia based on maternal body mass index (BMI).

Study design: This was a cross-sectional study among third-trimester pregnancies with preeclampsia (PIH) compared with normotensive controls. Serum levels of adiponectin, leptin, and resistin were measured before delivery by radioimmunoassay or enzyme-linked immunosorbent assay (ELISA).

Results: The study included 22 normotensive and 77 PIH women. Leptin levels increased with maternal BMI. In patients with severe preeclampsia, overweight, and obese women had increased leptin levels (33.4 +/- 14.8 vs 23.0 +/- 10.8 ng/mL respectively, P = .02), and decreased adiponectin levels (8.4 +/- 5.3 vs 12.6 +/- 6.0 ng/mL, P = .03) compared with normal weight women. In women with BMI <25 kg/m2, adiponectin levels increased in patients with preeclampsia compared with controls (11.5 +/- 5.6 vs 9.6 +/- 4.6 and 7.0 +/- 3.2 ng/mL, respectively, P = .005). There was no association between resistin levels and preeclampsia or maternal BMI.

Conclusion: Women with severe preeclampsia and BMI > or = 25 kg/m2 have decreased adiponectin and increased leptin levels, while normal weight women with preeclampsia have increased adiponectin levels.

Publication types

  • Comparative Study

MeSH terms

  • Adiponectin
  • Body Mass Index*
  • Cross-Sectional Studies
  • Female
  • Hormones, Ectopic / blood*
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood*
  • Leptin / blood*
  • Obesity / blood*
  • Pre-Eclampsia / blood*
  • Pre-Eclampsia / physiopathology
  • Pregnancy
  • Resistin

Substances

  • Adiponectin
  • Hormones, Ectopic
  • Intercellular Signaling Peptides and Proteins
  • Leptin
  • RETN protein, human
  • Resistin