Abstract
Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Bacterial / immunology
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Antibody Formation / immunology*
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Antibody Specificity
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Antigens, Bacterial / immunology
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Enzyme-Linked Immunosorbent Assay
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Hemagglutinins / immunology*
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Hemagglutinins / metabolism
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Humans
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Lectins
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Methylation
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Mycobacterium tuberculosis / immunology*
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Recombinant Proteins / immunology
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Tuberculosis, Pulmonary / diagnosis*
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Tuberculosis, Pulmonary / immunology*
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Hemagglutinins
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Lectins
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Recombinant Proteins
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heparin-binding hemagglutinin