The risk of cancer in HIV-infected people in southeast England: a cohort study

Br J Cancer. 2005 Jan 17;92(1):194-200. doi: 10.1038/sj.bjc.6602273.

Abstract

This study used data from the Communicable Disease Surveillance Centre's national HIV database and the Thames Cancer Registry to assess the risk of cancer in HIV-infected people in southeast England. Among 26 080 HIV-infected men with 158,660 person-years follow-up, 1851 cancers, and among 7110 HIV-infected women (31 098 person-years), 171 cancers were identified. The standardised incidence ratio (SIR) for all non-AIDS-defining cancers was significantly increased in HIV-infected men (2.8, 95% confidence interval (CI) 2.6-3.1) but was nonsignificant in HIV-infected women (1.1, 95% CI 0.8-1.6). Most of the cancers observed were in men (n = 1559) and women (n = 127) with AIDS, and among them, the SIR for all non-AIDS-defining cancers was significantly increased in men (8.2, 95% CI 7.2-9.2) and women (2.8, 95% CI 1.6-4.6). The SIR for all non-AIDS-defining cancers was only just significantly increased in men with HIV-infection but not AIDS (1.2, 95% CI 1.0-1.5) and was nonsignificant in such women (0.8, 95% CI 0.5-1.2).

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / epidemiology*
  • Cohort Studies
  • Comorbidity
  • England / epidemiology
  • Feasibility Studies
  • Female
  • HIV Infections / complications
  • HIV Infections / epidemiology*
  • Humans
  • Incidence
  • Male
  • Neoplasms / complications
  • Neoplasms / epidemiology*
  • Registries
  • Retrospective Studies
  • Risk Factors