Objective: To investigate the expression and its significances of intercellular adhesion molecule-1 (ICAM-1) and interleukin-6 (IL-6) in nasal and bronchial mocosa in allergic rhinitis.
Method: Samples of nasal and bronchial mucosa were from 28 patients with allergic rhinitis and 12 controls and their paraffin sections were studied with immuno histochemical technique staining with ICAM-1 monoclonal antibodies and IL-6 polyclonal antibodies.
Result: The positive expression percentage of ICAM-1 in mucosa of nasal and bronchial in patients with allergic rhinitis were 100% and 92.86%. No difference were observed between them, P>0.05. But in the group of controls, those were obviously lower (66.67% and 58.33%). The difference between them was significant, P<0.05. The positive expression percentage of IL-6 in mucosa of nasal and bronchial in patients with allergic rhinitis were 100% and 82.14%. No difference were observed between them, P>0.05. But in the group of normal controls, those were obviously lower (41.67% and 41.67%). The difference between them was significant, P<0.05.
Conclusion: ICAM-1 and IL-6 are important cytokines in the allergic inflammation in airway. The closely correlation was observed between the allergic inflammation in upper and lower airway, so that the upper and lower airway should be treated as a united one. To otorhinolaryngologists and respiratory doctors, it is safe and efficient treatment to treat the inflammatory diseases in upper and lower airway at the same time.