Alpha1-antitrypsin deficiency--a model for conformational diseases

N Engl J Med. 2002 Jan 3;346(1):45-53. doi: 10.1056/NEJMra010772.
No abstract available

Publication types

  • Review

MeSH terms

  • Dementia / etiology
  • Dementia / therapy
  • Emphysema / etiology
  • Endopeptidases / metabolism*
  • Humans
  • Liver Cirrhosis / etiology
  • Models, Biological
  • Mutation
  • Neurodegenerative Diseases / etiology
  • Neurodegenerative Diseases / therapy
  • Protease Inhibitors / metabolism*
  • Protein Conformation*
  • Serpins / chemistry
  • Serpins / genetics
  • Serpins / metabolism*
  • alpha 1-Antitrypsin / chemistry
  • alpha 1-Antitrypsin Deficiency / metabolism*

Substances

  • Protease Inhibitors
  • Serpins
  • alpha 1-Antitrypsin
  • Endopeptidases