Aetiology and outcome of pneumonia in human immunodeficiency virus-infected children hospitalized in South Africa

Acta Paediatr. 2001 Feb;90(2):119-25.

Abstract

To determine the aetiology and outcome of pneumonia in human immunodeficiency virus (HIV)-infected children, we prospectively investigated 250 children hospitalized with pneumonia who were known or clinically suspected to be HIV-positive, or who required intensive care support in Cape Town, South Africa. Blood culture, induced sputum or bronchoalveolar lavage, nasopharyngeal aspirate and gastric lavage were performed. Of the total, 151 children (60.4%) were HIV-infected. Pneumocystis carinii pneumonia (PCP), occurring in 19 (7.6%) children (15 HIV-positive), was the AIDS-defining infection in 20.3%. The incidence and type of bacteraemia (14.3%) were similar in HIV-positive and HIV-negative patients; S. pneumoniae (5%) and S. aureus (2%) were the predominant isolates. Sputum or BAL cultures yielded bacteria in 145 of 243 (60%) specimens; viruses were cultured in 37 (15.2%). Bacterial prevalence (including M. tuberculosis in 8%) and anti-microbial resistance did not differ by HIV status except for S. aureus which was more common in HIV-infected children. Thirty-one (20%) HIV-positive and 8 (8%) HIV-negative children died [RR 1.16 (95% CI 1.05-1.28), p=0.008]; using multiple logistic regression, PCP was the only risk factor for mortality (p = 0.03).

Conclusion: In South Africa, PCP is an important AIDS-defining infection in children; bacterial pathogens occur commonly and with a similar prevalence in HIV-positive and HIV-negative children hospitalized for pneumonia. HIV-infected children with pneumonia have a worse outcome than HIV-negative patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • HIV Seropositivity / mortality
  • HIV Seropositivity / rehabilitation*
  • Hospitalization
  • Humans
  • Incidence
  • Infant
  • Male
  • Oxygen / therapeutic use
  • Pneumocystis Infections / drug therapy*
  • Pneumocystis Infections / epidemiology
  • Pneumocystis Infections / microbiology*
  • Pneumonia / microbiology*
  • Pneumonia / mortality
  • Pneumonia / therapy*
  • Positive-Pressure Respiration / methods
  • Prospective Studies
  • Risk Factors
  • South Africa / epidemiology
  • Staphylococcal Infections / epidemiology
  • Staphylococcal Infections / microbiology

Substances

  • Oxygen