Chest
Clinical InvestigationsClinical Efficacy and Safety of Thoracoscopic Talc Pleurodesis in Malignant Pleural Effusions
Section snippets
Patients
One hundred two consecutive patients with documented rapidly recurrent MPE (57 men and 45 women; median age, 66 years; age range, 20 to 83 years) who underwent medical thoracoscopy and TTP between January 1999 and December 2001 were included. Only those patients who were judged to be capable of undergoing this procedure were enrolled in the study. The patients with a poor performance status who were unable to care for themselves were excluded from the procedure. Chest radiography and thoracic
Results
One hundred two patients were treated within the 3-year survey period. The presenting symptom in the majority of patients (86.3%) was dyspnea. Also common was cough (22.5%) and thoracic pain (23.5%) as secondary symptoms. The characteristics of the study population are noted in Table 1. The main tumor types were lung cancer (n = 48), breast cancer (n = 16), and malignant pleural mesothelioma (n = 10), and the remainder was a heterogeneous group of malignancies. Median duration of suction
Discussion
In symptomatic patients with recurrent MPE of known or unknown etiology, medical thorascopy and TTP is recommended.1, 13, 14, 15 Talc is superior to other agents in producing pleurodesis,16 but the clinical success rate of TTP varies, and the safety of this procedure is currently being intensively discussed. Therefore, we conducted this analysis in order to address both issues.
Unfortunately, the definition of success, as well as the length of follow-up, differs in the literature, which
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A phase II study of bevacizumab with carboplatin-pemetrexed in non-squamous non-small cell lung carcinoma patients with malignant pleural effusions: North East Japan Study Group Trial NEJ013A
2016, Lung CancerCitation Excerpt :Pleurodesis is unlikely to be successful when the lung is not fully expanded after drainage [3]. Prospective studies of intrapleural therapy with talc or bleomycin for patients with MPE reported that the success rate for controlling pleural effusions was 37–84% at 3 months from the start of treatment [5–10]. In a Japanese study, pleurodesis with OK-432 (a Streptococcus pyogenes preparation) was found to be more effective than intra-pleural injections of bleomycin [11].
Therapeutic thoracentesis symptoms and activity: A qualitative study
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2022, Zdravniski VestnikComplications of thoracoscopic talc insufflation for the treatment of malignant pleural effusions: a meta-analysis
2021, Journal of Cardiothoracic SurgerySurvival and pleurodesis outcome in patients with malignant pleural effusion - a systematic review
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