Chest
Opinions/HypothesesTissue Reparative Effects of Macrolide Antibiotics in Chronic Inflammatory Sinopulmonary Diseases
Section snippets
Chronic Rhinosinusitis and Nasal Polyps
Chronic sinusitis, a common disease of the paranasal sinuses, is characterized by purulent sinus effusion and nasal discharge.16 Neutrophils play an important role in regulating the inflammatory process by secreting various pro-inflammatory cytokines, such as interleukin (IL)-8.17 Fourteen-membered ring macrolide antibiotics, such as erythromycin and clarithromycin, are efficacious in chronic sinusitis.8181920 Patients administered low-dose clarithromycin8 or roxithromycin (not available in the
Conclusion
Long-term, low-dose administration of 14- and 15-membered ring macrolide antibiotics is associated with salutary tissue reparative effects in patients with chronic inflammatory sinopulmonary diseases such as chronic sinusitis, asthma, bronchiectasis, cystic fibrosis, and diffuse panbronchiolitis that are distinct from their anti-infective properties. Overall, these responses are associated with down-regulation of the nonspecific host inflammatory response to injury in these tissues.
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Cited by (0)
Dr. Garey is on the Speakers' Bureau for Abbott Laboratories and Aventis Pharmaceuticals. Dr. Danziger is on the Speakers' Bureau and has received research grants from Abbott Laboratories, Ortho-McNeil Pharmaceuticals, AstraZeneca Pharmaceuticals, and Merck & Co.
Dr. Rubinstein is on the Speakers' Bureau and has received research grants from Abbott Laboratories, Aventis Pharmaceuticals, GlaxoSmithKline, and Chiron. Financial support for this review was provided by the University of Illinois at Chicago and Abbott Laboratories.