Chest
Clinical InvestigationsLeft Ventricular Systolic Dysfunction in Patients with Obstructive Sleep Apnea Syndrome
Section snippets
Patients
The study population included patients with OSAS diagnosed by polysomnography (apnea-hypopnea index [AHI] > 10 events per hour) consecutively admitted to our Department of Pneumology over a 5-year period for the administration of nasal CPAP. In these patients, LVEF was systematically measured using radionuclide angiography as part of a routine evaluation.
Exclusion Criteria
Exclusion criteria were as follows: (1) central sleep apnea, defined as a central apnea index (AI) > 5/h associated with an obstructive AI <
Results
The main characteristics of the patients are summarized in Table 1. The study population included 169 OSAS patients with a mean AHI of 47/h. The AHI was > 30/h in 71% of the patients, and > 50/h in 41%. Seventy-nine percent of the patients were obese, with massive obesity in 37%.
Radionuclide angiography could be performed in all patients without any technical failure. LV systolic dysfunction was present in 7.7% (13 of 169 patients) of the study population, and these patients had a mean LVEF of
Discussion
This study showed that left ventricular systolic dysfunction, diagnosed by radionuclide angiography, was observed in 7.7% (13 of 169 patients) with OSAS requiring nasal CPAP, and with no associated cardiac disease. LV function impairment was moderate, as the lowest value of LVEF was 32%. In the seven patients with LV dysfunction in whom a second measurement of LVEF could be obtained following efficient treatment of OSAS, LVEF improved significantly and reached normal values in all of them.
This
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