Chest
Bronchiolitis Obliterans Organizing Pneumonia Associated with Systemic Lupus Erythematosus
Section snippets
CASE 1
A 54-year-old white man with a history of SLE was admitted to the hospital for evaluation of dyspnea, hypoxemia, and bilateral pulmonary infiltrates. Seven months earlier, he had presented with pleuritic chest pain and bilateral pleural effusions. The serum antinuclear antibody (ANA) titer was 1:2560 homogeneous, the antidouble stranded DNA antibody titer was 1:80, and pleural fluid analysis revealed a positive ANA titer and a positive LE cell smear. A diagnosis of SLE was made, and a regimen
DISCUSSION
Bronchiolitis obliterans organizing pneumonia is a pathologic pattern which is characterized by the formation of plugs of fibrous tissue within small airways and alveolar ducts, typically accompanied by inflammatory changes involving bronchioles and the surrounding interstitium.6, 7, 8 Although the precise mechanism of injury leading to the formation of BOOP is unclear, recent pathologic studies suggest that injury to the alveolar epithelium may play an important role.7, 8 Although this
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