Journal of the American Academy of Child & Adolescent Psychiatry
ArticlesPsychophysiologic Reactivity in Asthmatic Children: A Cholinergically Mediated Confluence of Pathways
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Association between childhood maltreatment and atopy in the UK: A population based retrospective cohort study
2022, eClinicalMedicineCitation Excerpt :Exposure to stress, such as childhood maltreatment, activates the sympathetic nervous system and suppresses the parasympathetic nervous system, resulting in alterations in vagal tone which regulates bronchial contractility.35 Miller et al. previously demonstrated that emotional responsivity and increased vagal reactivity were associated with increased airway reactivity and decreased pulmonary function in children with asthma.36 Emin et al. also demonstrated a dose response relationship between autonomic nervous system dysfunction and asthma severity.37
Ozone-induced enhancement of airway hyperreactivity in rhesus macaques: Effects of antioxidant treatment
2020, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Indeed, approximately 60% of stressed macaques in this cohort had AHR in the absence of atopy (by skin test to common aeroallergens12) or T-cell activation in the periphery.12 AHR in these animals is thought to be driven by autonomic neuronal dysregulation of the airways,12,13,44 leading to development of TH2-low asthma.41,45 Social stress and AHR have been also associated with glucocorticoid receptor dysfunction, significantly contributing to airway changes and complicating therapeutic efforts in TH2-low asthma.46-48
Clinical Potentials for Measuring Stress in Youth with Asthma
2011, Immunology and Allergy Clinics of North AmericaCitation Excerpt :Assuming the subjects have been randomly assigned in sufficient numbers to stressor versus control conditions, the researcher can make causal inferences about the influence of the manipulation, without concerns about confounding variables playing a role. One laboratory manipulation suggests that emotional responsivity may mediate the relationship between psychological stress and asthma outcomes.41 As part of this study, youth with asthma watched several segments from the movie, E.T., The Extra-terrestrial.
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This work was supported in part by a Clinical Research Center Grant to Dr. Miller from the National Jewish Center for Immunology and Respiratory Medicine, and in part by funding from the Department of Psychiatry at the University of Rochester School of Medicine and Dentistry. The authors thank Drs. David Mrazek and Bruce Bender for their professional contributions to this effort, William Orr and Isaac George for their technical assistance, and their patients for participation in this study.
Dr. Miller dedicates this paper to the memory of Haroutun M. Babigian, M.D., who as Chairman, mentor, and friend at the University of Rochester provided support and encouragement for this work.