Letter to the editorConsistency of sputum eosinophilia in difficult-to-treat asthma: A 5-year follow-up study
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Asthmatics with concordant eosinophilic disease classified according to their serum IgE status
2021, Respiratory Medicine and ResearchCitation Excerpt :Thirdly, it can be argued that the value of our classification may be limited by the uncertain stability of the eosinophilic trait and IgE levels over time. However, patients with blood eosinophils over 400 are often persistently eosinophilic [36] and sputum eosinophils above 3% show a rather good stability over time, in particular in those patients already treated by ICS [37,38]. There are limited data in the literature describing the stability of IgE measurements over time in asthmatic patients.
Baseline sputum eosinophil + neutrophil subgroups’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort
2020, Journal of Allergy and Clinical ImmunologyEosinophilic Asthma
2020, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Late-onset severe asthma with eosinophilic inflammation is now a well-recognized adult asthma phenotype and thought to be driven by different pathophysiological mechanisms than childhood-onset allergic asthma. It typically presents in the fourth or fifth decade of life and is characterized by TH2-high eosinophilic inflammation of the airway that persists despite inhaled corticosteroid therapy.6,32,33 Patients often have difficult to control asthma from disease onset and tend to develop fixed airways obstruction early in the disease course.34,35
Development of an automated ImmunoCAP research assay for eosinophil derived neurotoxin and its use in asthma diagnosis in children
2019, Practical Laboratory MedicineCitation Excerpt :Asthma is characterized by chronic airway inflammation in which eosinophils are thought to be central for the pathophysiological changes and airway remodeling [12]. In most individuals with asthma, the levels of eosinophils are elevated both in the airways and in the blood and there is a positive correlation between eosinophil counts and uncontrolled or severe asthma [13,14]. When the asthma is controlled, the eosinophil counts are usually lower [15].
Early decreases in blood eosinophil levels with reslizumab
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I.H.v.V. received an unrestricted educational grant from AstraZeneca.
Disclosure of potential conflict of interest: E. H. Bel received an unrestricted grant from GlaxoSmithKline, receives research support from Cambridge Antigen Technology, has provided legal consultation/expert witness testimony for PDL Biopharma and Schering-Plough, and is a member of the editorial board of the American Journal of Respiratory and Critical Care Medicine (AJRCCM) for the American Thoracic Society. The rest of the authors have declared that they have no conflict of interest.