Food allergy, dermatologic diseases, and anaphylaxisDifferential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology
Section snippets
Participants
The study was based on mother-child pairs enrolled in the Danish National Birth Cohort (DNBC)8. Women were invited to participate when they first consulted their general practitioner about the pregnancy. Participation involved 4 computer-assisted telephone interviews at gestational weeks 12 and 30 (first and second interview) and when the child was 6 and 18 months old (third and fourth interview). The DNBC has consecutively recruited 100,000 pregnant women from 1997 to 2002. In April 2000, the
Results
“Wheeze ever” and AD were significantly associated (crude OR, 1.31; 95% CI, 1.21-1.42)). This association remained significant after adjustment for risk factors (adjusted OR, 1.28; 95% CI, 1.19-1.39). Thus, the cumulated incidence of “wheeze ever” was 32.6% and 26.9% among infants with and without AD, respectively. The cumulated incidence of “recurrent wheeze” was 11.4% and 7.3% among infants with and without AD, respectively (adjusted OR, 1.30; 95% CI, 1.20-1.41).
The estimates for the effects
Discussion
We found that the majority of risk factors had differential effects on the risk of wheezing and AD. Most risk factors even had opposite direction of their effects on wheeze and AD. For example, breast-feeding was associated with a decreased risk of wheezing but an increased risk of AD. Hence, these findings support the notion that infant wheezing and AD have a different etiology.
The association between infant wheeze and AD observed in the current study was relatively weak (OR, 1.3). However,
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Prenatal, infantile, and childhood tobacco exposure and risk of pediatric psoriasis in the Danish National Birth Cohort offspring
2020, Journal of the American Academy of DermatologyHow does parental history of atopic disease predict the risk of atopic dermatitis in a child? A systematic review and meta-analysis
2020, Journal of Allergy and Clinical ImmunologyRelationship between birth weight or fetal growth rate and postnatal allergy: A systematic review
2019, Journal of Allergy and Clinical ImmunologyNeonatal BCG vaccination has no effect on recurrent wheeze in the first year of life: A randomized clinical trial
2017, Journal of Allergy and Clinical ImmunologyDuration of exclusive breastfeeding and wheezing in the first year of life: A longitudinal study
2017, Allergologia et ImmunopathologiaCitation Excerpt :Silver et al.4 found that the duration of exclusive breastfeeding was a stronger determinant of respiratory outcomes, including wheezing, than “any” breastfeeding at 15 months of age. Indeed, the relationship between exclusive breastfeeding and wheezing and/or other asthma-related outcomes has been scantily studied so far,4,20–25 possibly due to the complexity to conduct cohort studies collecting accurate data on infant feeding, prospectively. There is a need for studies based on large cohorts, strict eligibility criteria and definitions, longitudinal and accurate data, including continuous measurement of breastfeeding, while taking into account a minimum set of confounders.2,4–6,12–19
The role of maternal anxiety and depressive disorders prior to and during pregnancy and perinatal psychopathological symptoms for early infant diseases and drug administration
2017, Early Human DevelopmentCitation Excerpt :Although our results have to be interpreted with caution, because information on infants' health was based exclusively on maternal self-reports (see also Strengths and limitations), they suggest promising directions regarding our current knowledge about the relevance of perinatal maternal mental health for early infant diseases. The associations between maternal age [18], socioeconomic status [19], parity [20], and infants' sex [18] with infant skin complaints were in line with former studies, whereas the association of assisted delivery/C-section and skin complaints was not reported thus far. Interestingly, no significant relation appeared between severe maternal psychopathological symptoms during pregnancy and infant skin complaints as reported elsewhere [5,10,11].
The Danish National Research Foundation established the Danish Epidemiology Science Centre, which initiated and created the Danish National Birth Cohort. The cohort is a result of a major grant from this foundation. Additional support for the Danish National Birth Cohort was obtained from the Pharmacy Foundation of 1991, the Egmont Foundation, the March of Dimes Birth Defects Foundation, and the Augustinus Foundation.