Pathogenesis of Bronchiectasis
Section snippets
Cystic fibrosis: pathogenesis of bronchiectasis
Despite improvements in childhood health—nutrition, immunizations, tuberculosis control, and improved access to antibiotics—chronic pulmonary infections and bronchiectasis remain significant clinical issues worldwide. Bronchiectasis manifests differently among patients, particularly in the areas of inciting pathology, causative organisms, and prognosis. Specifically, cystic fibrosis (CF) typically follows a more severe clinical course than non-CF bronchiectasis. Despite these and other
Hygiene disruption in the cystic fibrosis airway
In the normal human respiratory tract, several components of innate immunity protect the respiratory tract from constant environmental exposures (particulates, microorganisms, oxygen, and so forth). Fundamental among these protections within the lower respiratory tract are airway clearance (primarily the mucociliary elevator), physicochemical barriers (represented by the mucus-sol constituents of the airway surface liquid [ASL]), and cell-based innate defenses.
Summary
Outlined in this article are the primary and acquired abnormalities of the CF airway that stimulate the genesis of and promulgate the pathology of bronchiectasis. Inflammation and infection are central causative mechanisms of bronchiectasis. Their persistence appears to disrupt orderly reparative processes in the airway. Modulation of these processes and controlling the positive feedback of bronchiectasis afford some braking effects on the inexorable respiratory decline in patients who have CF
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The therapeutic potential of CFTR modulators for COPD and other airway diseases
2017, Current Opinion in PharmacologyCitation Excerpt :Thus, whether non-allergic (possibly neutrophilic) or exacerbating asthma are conditions of CFTR dysfunction remains open to future investigation. Non-CF bronchiectasis (NCFBE) is a disorder characterized by neutrophilic inflammation and cyclical infection and mucus obstruction, much like CF and chronic bronchitis [35,36]. There is evidence that bronchiectasis may represent a spectrum of CFTR-related disorders as there are increased frequencies of CFTR mutations in patients in various studies [37].
Usefulness of High-resolution Computed Tomography for Macrolide Therapy of Idiopathic Bronchiectasis
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