The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma☆
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Mechanisms of airway hyperresponsiveness
2006, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Both desloratadine and fexofenadine have been shown to inhibit allergen-induced inflammation and airway hyperresponsiveness in mice,82-84 and this may result from the inhibition of TH2 CD4+-cell recruitment shown in H1 receptor knockout mice. However, H1 blockers have historically been ineffective in blocking allergen-induced LAR in human beings.85 Despite the numerous studies related to the mechanism of allergen-induced airway inflammation and the clear association with allergen-induced AHR, the precise mechanisms linking airway inflammation to the transient associated AHR remain elusive.86
Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma
2003, Journal of Allergy and Clinical ImmunologyThe single mediator approach to asthma therapy: Is it so unreasonable?
2003, Current Opinion in PharmacologyRole of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs
2002, Japanese Journal of PharmacologyInhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma
2001, Journal of Allergy and Clinical Immunology
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Supported in part by a programme grant from the British Medical Research Council.
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