Original articleSuperoxide generation and its modulation by adenosine in the neutrophils of subjects with asthma☆
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2018, ImmunobiologyCitation Excerpt :Contradictory data were obtained also in the remission period: without alterations in ROS level, as well as either increased or decreased ROS compared with healthy donors using luminol-dependent CL (Mattheyse et al., 2001; Monteseirin et al., 1996; Vargas et al., 1998). The isolated neutrophils of BA patients demonstrated increased ROS production in response to different stimuli estimated by various methods: reduction of cyt c (Meltzer et al., 1989; Styrt et al., 1988), nitroblue tetrazolium test (Mosca et al., 2015), lucigenin-dependent CL (Teramoto et al., 1996). Given that divergent results can be a consequence of the use of different methods for measuring ROS level (Caldefie-Chézet et al., 2002; Freitas et al., 2009; Monteseirín and Vega, 2011).
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2005, Archives of Medical ResearchCitation Excerpt :It has been suggested that reactive oxygen species (ROS) play an important role in the pathogenesis of airway inflammatory diseases (32,33). In asthma patients, a correlation has been found between the degree of bronchial responsiveness to methacholine and the production of superoxide anion by peripheral polymorphonuclear leukocytes (34,35). Katsumata et al. reported that ROS could induce bronchoconstriction and airway hyperresponsiveness in anesthetized cats (36).
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Supported by a grant from the Department of Research and Education, Kaiser Hospitals.
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Dr. P. Lad was supported in part by National Institutes of Health Grants AM30878 and AM34550.