Elsevier

Tubercle

Volume 66, Issue 4, December 1985, Pages 301-306

Hypothesis
A possible link between vitamin d deficiency and impaired host defence to mycobacterium tuberculosis

https://doi.org/10.1016/0041-3879(85)90068-6Get rights and content

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      Relationships between pathological conditions observed in modern populations form the basis for the assumptions that paleopathologists make about how disease may have been experienced in past populations, and lead to the development of paleopathological research questions. For example, epidemiological studies noting the co-occurrence, and possible causal relationship, between vitamin D deficiency and tuberculosis (e.g., Chan, 2000; Davies, 1985; Sita-Lumsden et al., 2007; Ustianowski et al., 2005; Wilkinson et al., 2000; Williams et al., 2008) led paleopathologists to ask whether these two conditions might also be associated in past populations (Roberts and Buikstra, 2003; Snoddy et al., 2016). Information on the occurrence of disease in modern populations is also essential for the interpretation of patterns observed in samples of ancient human skeletal material.

    • Role of essential trace elements in tuberculosis infection: A review article

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      Serum calcium perturbation is associated with vitamin D abnormalities.34 Vitamin D deficiency is correlated with the high TB incidence, especially in extrapulmonary TB.35 Iron: Iron is an essential element for MTB development.

    • Low serum 25-hydroxyvitamin D level: An independent risk factor for tuberculosis?

      2014, Clinical Nutrition
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      In TB disease, vitamin D may play anti-microbial and anti-inflammatory roles through modulating monocyte-macrophage activity and lymphocytes responses.6 Accordingly, vitamin D deficiency would leave the host more susceptible to TB disease by compromising the humoral immune defense.7 Several previous studies have compared vitamin D serum levels between TB patients and healthy control subjects,8,9 and have examined changes in vitamin D levels according to anti-TB treatment.10,11

    • Innate resistance to tuberculosis in man, cattle and laboratory animal models: Nipping disease in the bud?

      2014, Journal of Comparative Pathology
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      As far back as the mid-19th century there is evidence that vitamin D (initially in the form of cod liver oil) was beneficial in the treatment of TB in man and vitamin D was widely used for this purpose in the pre-antibiotic era (Martineau et al., 2007a; Green, 2011). Low serum 25-hydroxyvitamin D levels are associated with increased susceptibility to TB in man (Davies, 1985; Douglas et al., 1996; Chan, 1999; Wilkinson et al., 2000) and genetic polymorphisms in vitamin D receptors (VDRs) and vitamin D binding protein (DBP) are associated with susceptibility to TB, particularly when combined with low serum calcidiol (25[OH]D), the precursor of calcitriol (1,25[OH]2D), the active form of the vitamin (Martineau et al., 2010; Azad et al., 2012). In the context of innate immunity, the VDR is constitutively expressed in human peripheral monocytes and expression can be further upregulated by exposure to 1, 25[OH]2D.

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