Nitric oxide regulation of glycoconjugate secretion from feline and human airways in vitro
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2023, Pharmacology and TherapeuticsUtility of NO and H<inf>2</inf>S donating platforms in managing COVID-19: Rationale and promise
2022, Nitric Oxide - Biology and ChemistryCitation Excerpt :These actions are mediated through the cGMP pathway [165,166]. Additionally, NO increases mucus secretion, stimulating the feline and human submucosal glands by l-arginine and isosorbide dinitrate enhanced secretion activity [167]. Removing airborne pathogens from the respiratory tract provides the first part of the NO-linked antiviral defense.
Lifestyle-mediated nitric oxide boost to prevent SARS-CoV-2 infection: A perspective
2021, Nitric Oxide - Biology and ChemistryCitation Excerpt :In the respiratory tract, NO provides a first-line of defense against micro-organisms via its antiviral and antimicrobial activities. In airborne viral transmission to the airway, NO can physically remove the viral particles from the upper respiratory tract by activating ciliary movement [11] and mucus secretion in the airway epithelium [11,12]; aging and habitual smoking may eliminate this defensive ability and facilitate the viral invasion of the lower respiratory tract, where the virus can infect multiple cell types, including alveolar airway epithelial cells, alveolar macrophages, and vascular endothelial cells (Fig. 1). In the case of SARS-CoV-2, the viral spike (S)-protein, which is required for viral entry, has two regions, S1 and S2.
Integrity of airway epithelium in pediatric burn autopsies: Association with age and extent of burn injury
2015, BurnsCitation Excerpt :The airway epithelium is covered with an airway surface layer composed of mucus glycoproteins, antibacterial peptides and a tightly regulated water and electrolyte composition that provide rheological properties essential for cilia to move mucus with captured particulate matter and pathogens out of the airways [32]. Multiple factors that include both adrenergic and muscarinic receptors [33], in addition, to cytokines and other inflammatory mediators [34–36], nitric oxide [37], endothelin-1 [38,39] and purinergic receptors [40–42] contribute to airway homeostasis and mucociliary clearance. Thus, the physiological perturbations seen with burn injury may modify airway surface layer dynamics.
Non-invasive exploration of the airways: practical aspects in asthma and allergy
2006, Revue Francaise d'Allergologie et d'Immunologie CliniqueChronic exposure to TNF-α increases airway mucus gene expression in vivo
2005, Journal of Allergy and Clinical ImmunologyCitation Excerpt :TNF-α has also been shown in vitro to increase the expression of inducible nitric oxide synthase, which in turn produces nitric oxide.39,40 Nagaki et al41 demonstrated that the methacholine-induced increase in mucus glycoprotein secretion from feline and human airway submucosal glands was significantly inhibited by the nonselective nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). There could also be indirect effects of TNF-α on mucus gene expression.