Case reportLung lavage (alveolar washing) in alveolar proteinosis☆
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Cited by (54)
Correction of a chronic pulmonary disease through lentiviral vector-mediated protein expression
2022, Molecular Therapy Methods and Clinical DevelopmentCitation Excerpt :About 90% of PAP cases are caused by generation of anti-GM-CSF autoantibodies,10 which prevent adequate GM-CSF-mediated surfactant clearance by alveolar macrophages.11–14 The standard of care is whole-lung lavage,15,16 an invasive technique where the lipoproteinaceous surfactant is washed out of each lung in turn under anesthesia at regular intervals. Inevitably, the intervention is associated with complications17 and is only performed in specialist centers.6,18
Pulmonary Alveolar Proteinosis Syndrome
2015, Murray and Nadel's Textbook of Respiratory Medicine: Volume 1,2, Sixth EditionAutoimmune pulmonary alveolar proteinosis: Clinical course and diagnostic criteria
2014, Autoimmunity ReviewsCitation Excerpt :Despite the apparent autoimmune mechanism of acquired PAP, immunosuppressive therapy is not the first line therapy. Mechanical removal of the sediment by whole lung lavage, first performed by Ramirez et al. [37], described in detail by Wasserman et al. [38] and later modified [35,39,40], remains the standard therapy. Lung lavage is effective in 60% or more [1,41,42].
Pulmonary alveolar proteinosis: Step-by-step perioperative care of whole lung lavage procedure
2002, Heart and Lung: Journal of Acute and Critical CareCitation Excerpt :We believe that hypoxemia, at rest or with mild activities, should be considered an indication for WLL, especially if the hypoxia is progressive and/or effort intolerance interferes with the patient's lifestyle. Since first described,3 WLL has been attempted in persons with PAP, asthma,7 and cystic fibrosis.13 During WLL, body oxygenation must be supported by ventilating 1 lung which has a deranged gas exchange.
Silicoproteinosis in a mining patient in Colombia. Case report
2023, Medicina y LaboratorioA mini-whole lung lavage to treat autoimmune pulmonary alveolar proteinosis (PAP)
2022, Respiratory Research
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This study was supported in part by Public Health Grants HE 06591 and HE 03043 and The John A. Hartford Foundation.
- 1
From The Departments of Medicine, Radiology and Anesthesiology, Stanford University School of Medicine,Palo Alto, California.
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Present address: Department of Medicine, U.C.L.A. School of Medicine, Respiratory Disease Division, Harbor General Hospital, 1000 West Carson Street, Torrance, California 90502.