eLetters

234 e-Letters

  • The authors’ response to Dr Quanjer
    Pim A de Jong

    Dear Editor,

    We appreciate the comments made by Prof. Quanjer concerning our manuscript (1) and fully agree with his comments. In his letter to the editor Prof. Quanjer gives valuable background information to the reasons why pulmonary function tests are relatively insensitive to track pulmonary changes in the longitudinal follow up of cystic fibrosis (CF) lung disease (2). We agree with his arguments that this is...

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  • Single- or multi-detector row CT in diagnosing PE: a never ending debate?
    Mathilde Nijkeuter

    Dear Editor,

    We would like to comment to the limitations of the Christopher-study (JAMA 2006;295) mentioned by Dr. Bari. He states that “the limitations of this study include the use of two different kinds of CT scanner (multi- detector and single-detector) with potentially different pick up rates”. The other limitation stated is: “the prevalence of PE of 23.2% in the ‘clinically unlikely PE and abnormal D-dimer’...

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  • Complexities of pulmonary dysfunction following cardiopulmonary bypass
    Calvin S.H. Ng

    Dear Editor,

    We congratulate Elkington and Friedland on their excellent review which gives an overview of matrix metalloproteinases (MMPs) in various destructive pulmonary diseases.[1] MMPs and neutrophil elastase do indeed play instrumental roles in the development of ARDS and lung injury following cardiopulmonary bypass (CPB), however, the mechanisms presented may be too simplified.[2]

    Apart from...

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  • Exercise induced bronchoconstriction (EIB) in elite athletes: measuring the fall ?
    Martin R. Lindley

    Dear Editor,

    We read with great interest the article published in Thorax by Dickinson et al (February 2006)(1) investigating the response of FEF50 following EVH (Eucapnic voluntary hyperventilation) or exercise challenges in elite athletes as an adjunct to FEV1.0. We were however, slightly confused as to the research design selected by the researchers. It appears from the stated methods that the researchers used...

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  • The hygiene hypothesis revisited
    Wendy J Anderson

    Dear Editor,

    The editorial by Cullinan suggests that the relationship between allergy, birth order and family size may not be completely explained by the hygiene hypothesis.[1] A role for infection in protecting against allergy has been under consideration for some years, although a credible mechanism has not been identified. It has been suggested that reduced exposure to infection in childhood shifted the balanc...

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  • May local referral patterns have influenced hospital data on lung cancer?
    Wendy J A Anderson

    Dear Editor,

    Imperatori et al. make a detailed comparison of lung cancer patients, management and survival in two hospitals, one in England and one in Italy, in an attempt to throw some light on the differences in published survival between these nations[1]. In collecting similar data we have found between 5 and 10% of the patients in our geographical catchment area have not attended our hospital either as in-patie...

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  • Misinterpretation continues of asthma and allergies trends in Germany
    Wasim Maziak

    Dear Editor,

    The correction by Zollner diverts the main issue we raised from incorrectly citing our study as supporting the decrease/leveling off of asthma and allergies in Germany when our study showed an increase, to a reference order error [1]. Also, in Zollner's reply our data were again misinterpreted, as we showed clearly for example that symptoms of asthma, rhinitis, and rhino-conjunctivitis increased sig...

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  • Cross-correlation with your research re: food influences on asthma
    Cedric Beniston

    Dear Editor,

    I was very interested to read of your research on the effect of tomatoes, carrots, and leafy vegetables in reducing asthma.

    A large-scale experiment to test these theories in practice, would be to obtain the statistics for the population of Italy, where tomatoes (especially) are an integral part of the national diet, and basil (a green leafy vegetable) is nearly always included in tomato dis...

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  • Household chemicals and persistent wheeze: Is there a link?
    Andrew N Williams

    Dear Editor,

    Sherriff and colleagues report an apparent association between mothers’ self-reported frequency of use of assorted household ‘chemicals’ during pregnancy and ‘persistent wheeze’ in their offspring. Since their paper suggests this may help explain recent rises in asthma, the robustness of the data and other explanations for the observed statistical association need careful consideration.

    We...

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  • Pulmonary function tests in following up cystic fibrosis
    Philip H. Quanjer

    I read with great interest the paper by de Jong et al. [1]. The authors conclude from a carefully conducted study that scores derived from CT scans are more sensitive in detecting progression of cystic fibrosis in children and adults than pulmonary function tests. I have no difficulty in accepting any such outcome. However, it seems that undue reliance was placed on predicted pulmonary indices, and...

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