eLetters

224 e-Letters

  • Socioeconomic gradient related to respiratory complaints in pupils
    Coppieters Yves

    Dear Editor

    Such as the paper from Dales et al. concerning the influence of family income on asthma morbidity,[1] understanding socioeconomic effects on adolescent health is a critical and important area of research if we are to eliminate health disparities.[2] Moreover, traditionally used tools to evaluate socio-economic gradient are difficult to construct within this population and new indicators must...

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  • HIV and TB
    Bello S Oricha

    Dear Editor

    The relationship between HIV and tuberculosis are probably predictable. Both are lentiform diseases and immuno suppressive. Primary tuberculous lesions may be re-activated in an immuno suppressive state and new infections are more easily established. The real danger is that one partner (tuberculosis) of this vicious circle is transferable by droplet infection and in its presence the precaution required o...

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  • Are type 1 and type 2 reponses really reciprocal?
    Wendy JA Anderson

    Dear Editor

    I read with interest the paper by Papadopoulos et al. describing the balance between type 1 and type 2 responses by CD4 and CD8 T lymphocytes in atopic asthmatics and normal subjects stimulated by rhinovirus. They state that their data is consistent with ‘reciprocal regulation of type 1 and type 2 responses’. Their figure demonstrates that in both normals and atopic asthmatics interferon gamma and in...

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  • High-dose of Fluticasone propionate in mild asthmatics
    S K Agarwal

    Dear Editor

    In a study [1] by Ward et al the dose of fluticasone propionate used for mild asthmatics was several folds higher (1500 mcg) whereas the recommended dose in different International guidelines is only 200 mcg.The other flaws which need clarification are:
    a) Inhaled corticosteroid was withdrawn 3 months before putting the patients on this study; there is no mention of the number of puffs o...

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  • COPD outcomes in ICU
    Luke S Howard

    Dear Editor

    The data presented by Breen et al[1] regarding the outcomes of patients with COPD are encouraging and lend support to the respiratory physician often faced with nihilistic attitudes towards ventilating these patients in acute respiratory failure. However, despite the proposition by the authors that certain patients with likely poor outcomes might have been excluded, the ICU stays for both gr...

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  • ETS and asthma: U shaped effect? - Author's response
    Dear Editor

    Dr McFadden is putting forward an interpretation of the small non- significant decrease in asthma episode contacts seen amongst those with moderate exposure to passive smoking. In our view this is unwise. The effect could well be due simply to the play of chance. Further we have shown that non-clinical factors have a dominant influence on visit frequency and that the frequency of contacts is a poor measu...

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  • Obesity is associated with respiratory problems, not necessarily asthma - Author's response
    Dear Editor,

    We fully appreciate Dr Furness's comments on the limitations of the definition of asthma based on parents' reports of symptoms and we have contributed on the subject.[1] Epidemiological studies of asthma have to rely on reported symptoms,[2][3] but a better understanding of what parents call wheeze would be of great importance, especially in a multicultural society. The validity of reported asthma symptoms...

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  • Intravenous IL-5 antagonist in bronchial asthma
    Dear Editor,

    Intravenous interleukin-5 antagonist has great potential and studies have shown that it may be beneficial in chronic asthmatics for 3 to 6 months.

    Now the understanding of cytokines and their beneficial and harmful effects are well known but still cure of bronchial asthma appears to be a remote possibility. Non-compliance in patients is very high and once they feel better they take medicines irre...

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  • Statistical error or not?
    Dear Editor,

    I read with great interest the article of Nakayama et al about tuberculin responses and risk of pneumonia in immobile elderly patients. It is known that TH1 cells are important in delayed type hypersensitivity responses to tuberculin. The authors' findings are important in assessment of pathogenesis of pneumonia in elderly patients. But I have some doubts about the analysis of data. The groups were compared...

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  • Obesity is associated with respiratory problems, not necessarily asthma
    Dear Editor,

    I was interested to see the work of Figueroa-Munoz and colleagues showing an association between obesity and wheeze.[1] I would like to caution against their conclusion. In their study asthma is defined according to "asthma attack" and parental reports of wheeze. Several studies have shown parental reporting of wheeze to be unreliable.[2][3][4]

    Please can the authors clarify who defined, "asthma att...

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