eLetters

219 e-Letters

  • Pulmonary rehabilitation for patients with COPD: integrated care or home alone?
    Lowie E.G.W. Vanfleteren

    Based on their findings from a prospective, randomized, controlled equivalence trial, Holland and colleagues conclude that a 8-week home- based rehabilitation model produced short-term clinical outcomes that were equivalent to a center-based pulmonary rehabilitation program.[1] To their credit, the authors' recruitment and statistical design were of high quality, as were the outcome measures used. We acknowledge that the...

    Show More
  • Hypotheses to explain the reduced sensitivity of tuberculin skin test in BCG immunised young children
    Michael Eisenhut

    In a recent cohort study investigating tuberculin skin test (TST) in relation to interferon gamma release assay (IGRA) responses in exposed children and relating responses to previous BCG immunisation the authors reported a reduced sensitivity of TST using IGRA as a reference standard at all induration thresholds for young children (less than 5 years old) who had a previous BCG immunisation compared to those who didn't(1...

    Show More
  • Neurohumoral activation as a link between FEV1 and CVD
    Stefan Andreas

    Dear Editor,

    with the greatest interest I have read the publication "Lung function and airway obstruction: associations with circulating markers of cardiac function and incident heart failure in older men--the British Regional Heart Study" by Wannamethee et al. (Thorax 2016 71:526-534). Analyzing a large database with 13 years of prospective follow up the authors conclude that "reduced FEV1 reflecting airflow ob...

    Show More
  • Authors Reponse: Exercise induced bronchoconstriction (EIB) in elite athletes: measuring the fall ?
    John W Dickinson

    Dear Editor,

    We would like to thank Lindley and Mickleborough for their comments on our paper (1) recently published in the Thorax journal. We agree that eucapnic voluntary hyperventilation (EVH) challenges provide greater sensitivity when compared with exercise challenges in the diagnosis of EIA in elite athletes and have recently published data supporting this hypothesis (2). Despite the greater sensitivity pr...

    Show More
  • Doubting the efficacy of pneumococcal vaccination
    Alyn H Morice

    Dear Editor,

    I read with interest the paper by Alfageme and colleagues (1) who investigated the efficacy of anti-pneumococcal vaccination in patients with COPD. To have new data in an area which has suffered from a surfeit of meta-analysis and even analysis of the meta-analysis is good and their results are quite clear. Although they do not specifically comment I presume that their primary end point was accum...

    Show More
  • The authors’ response to Dr Quanjer
    Pim A de Jong

    Dear Editor,

    We appreciate the comments made by Prof. Quanjer concerning our manuscript (1) and fully agree with his comments. In his letter to the editor Prof. Quanjer gives valuable background information to the reasons why pulmonary function tests are relatively insensitive to track pulmonary changes in the longitudinal follow up of cystic fibrosis (CF) lung disease (2). We agree with his arguments that this is...

    Show More
  • Single- or multi-detector row CT in diagnosing PE: a never ending debate?
    Mathilde Nijkeuter

    Dear Editor,

    We would like to comment to the limitations of the Christopher-study (JAMA 2006;295) mentioned by Dr. Bari. He states that “the limitations of this study include the use of two different kinds of CT scanner (multi- detector and single-detector) with potentially different pick up rates”. The other limitation stated is: “the prevalence of PE of 23.2% in the ‘clinically unlikely PE and abnormal D-dimer’...

    Show More
  • Complexities of pulmonary dysfunction following cardiopulmonary bypass
    Calvin S.H. Ng

    Dear Editor,

    We congratulate Elkington and Friedland on their excellent review which gives an overview of matrix metalloproteinases (MMPs) in various destructive pulmonary diseases.[1] MMPs and neutrophil elastase do indeed play instrumental roles in the development of ARDS and lung injury following cardiopulmonary bypass (CPB), however, the mechanisms presented may be too simplified.[2]

    Apart from...

    Show More
  • Exercise induced bronchoconstriction (EIB) in elite athletes: measuring the fall ?
    Martin R. Lindley

    Dear Editor,

    We read with great interest the article published in Thorax by Dickinson et al (February 2006)(1) investigating the response of FEF50 following EVH (Eucapnic voluntary hyperventilation) or exercise challenges in elite athletes as an adjunct to FEV1.0. We were however, slightly confused as to the research design selected by the researchers. It appears from the stated methods that the researchers used...

    Show More
  • The hygiene hypothesis revisited
    Wendy J Anderson

    Dear Editor,

    The editorial by Cullinan suggests that the relationship between allergy, birth order and family size may not be completely explained by the hygiene hypothesis.[1] A role for infection in protecting against allergy has been under consideration for some years, although a credible mechanism has not been identified. It has been suggested that reduced exposure to infection in childhood shifted the balanc...

    Show More

Pages