Prematurity and bronchopulmonary dysplasia (BPD) affect long-term lung function. We studied the respiratory outcome of adolescents born very preterm and controls from the Etude EPIdémiologique sur les Petits Ages Gestationnels cohort and analysed their current lung function in relation to asthma symptoms (categorised in three age groups) from birth. In models including BPD, asthma at each age and confounding factors in the preterm group, BPD and preschool wheeze were the only independent variables associated with FEV1. Preschool wheeze is an independent factor associated with FEV1 impairment in adolescents born very preterm. These results highlight the need for optimal management of early respiratory symptoms in preterm-born infants.
Trial registration number Results, NCT01424553.
- paediatric asthma
- paediatric lung disaese
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Contributors Study concept and design: AH, CD, CA, J-CR, SM and P-YA. Data acquisition: CD, MM, MV, LC, AB and the members of the EPIPAGEADO study group. Analysis and interpretation of data: AH, CD, P-YA and JR. Drafting the article: AH, CD, P-YA and JR. Critical revision of the manuscript for important intellectual content: AH, CD, P-YA. CA, J-CR, SM, MM, MV, LC, JR and the members of the EPIPAGEADO study group. Final approval of the version to be published: AH, CD, P-YA, JR, AB, CA, J-CR, SM, MM, MV, LC, and the members of the EPIPAGEADO study group. AH and P-YA had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Funding The EPIPAGEADO study was sponsored by the Assistance Publique-Hôpitaux de Paris (Département de la Recherche Clinique et de Développement). The study was funded by a grant from the Programme Hospitalier de Recherche Clinique (PHRC) 2010 (Ministère de la Santé, N°AOM P100117). AH was funded by l’Agence Nationale de la Recherche (ANR-12-BSV1-0004-01).
Competing interests None declared.
Patient consent Obtained.
Ethics approval Local ethics committee: CPP Île-de-France VI.
Provenance and peer review Not commissioned; externally peer reviewed.
Collaborators The EPIPAGEADO study group includes: François Brémont; Maryline Delattre; Monique Kaminski; Géraldine Labouret; Muriel Lebourgeois; Christophe Marguet; Marie-Carole Paruit; Laetitia Peaudecerf; Catherine Tardif.
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