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Smoking, telomere length and lung function decline: a longitudinal population-based study
  1. Pascal Andujar1,2,3,
  2. Dominique Courbon4,5,
  3. Emilie Bizard2,
  4. Elisabeth Marcos2,
  5. Serge Adnot1,2,6,
  6. Laurent Boyer1,2,6,
  7. Pascal Demoly7,8,
  8. Debbie Jarvis9,10,
  9. Catherine Neukirch4,11,
  10. Isabelle Pin12,13,14,
  11. Gabriel Thabut4,15,
  12. Jorge Boczkowski1,2,6,
  13. Bénédicte Leynaert4,5
  1. 1Université Paris Est-Créteil,Faculté de Médecine, Créteil, France
  2. 2INSERM, U955, DHU ATV-B, Créteil, France
  3. 3CHI Créteil,Service de Pneumologie et Pathologie Professionnelle, Créteil, France
  4. 4INSERM, UMR1152, Paris, France
  5. 5Université Paris-Diderot,DHU FIRE, Paris, France
  6. 6CHU Mondor, Créteil, France
  7. 7Department of Pulmonology, Division of Allergy, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
  8. 8Inserm,UMR-S 1136, UPMC, Université Paris 06, UMRS 1136, Equipe - EPAR - IPLESP, Sorbonne Universités, Paris, France
  9. 9Population Health and Occupational Disease, National Heart and Lung Institute, Imperial College, London
  10. 10MRC-PHE Centre for Environment and Health, Imperial College London, London, UK
  11. 11CHU Bichat, Service de Pneumologie A, Paris, France
  12. 12Université Grenoble-Alpes, Grenoble, France
  13. 13INSERM, U823, Grenoble, France
  14. 14CHU Grenoble-Alpes, Service de Pédiatrie, Grenoble, France
  15. 15CHU Bichat,Service de Pneumologie B, Paris, France
  1. Correspondence to Bénédicte Leynaert, INSERM UMR 1152, Faculté de Médecine site Xavier Bichat, 16 rue Henri Huchard, BP 416 75870, Paris cedex 18, FRANCE; benedicte.leynaert{at}inserm.fr

Abstract

Telomere shortening is associated with COPD and impaired lung function in cross-sectional studies, but there is no longitudinal study. We used data from 448 participants recruited as part of the French follow-up of the European Community Respiratory Health Survey. We found no relationship between telomere length at baseline and FEV1 decline after 11 years of follow-up. However, heavy smoking was associated with an accelerated FEV1 decline in individuals with short telomeres, but not in subjects with longer telomeres (p for interaction p=0.08). Our findings suggest that short telomere length in peripheral leucocytes might be a marker for increased susceptibility to the effect of smoking.

  • Tobacco and the lung
  • COPD epidemiology

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Footnotes

  • Contributors PA: Study design, interpretation of data and manuscript writing. JB: Idea of the study, participation in the editing and correction of the final text. DC: Study design, interpretation of data, statistical analysis and manuscript writing. BL: Study design, interpretation of data, and manuscript writing and coordination of the ECRHS study and data collection in French centres. IP: Coordination of the ECRHS study and data collection in French centres and participation in the editing and correction of the final text. PD: Coordination of data collection in a French centre and participation in the editing and correction of the final text. CN: Coordination of data collection in a French centre and participation in the editing and correction of the final text. DJ: Coordination of ECRHS international and participation in the editing and correction of the final text. GT: Participation in the editing and correction of the final text. EM: Biological analysis. EB: Biological analysis. LB: Biological analysis and participation in the editing and correction of the final text. SA: Participation in the editing and correction of the final text. All authors participated in the interpretation of the findings, reviewed the manuscript critically and approved the final version.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Comité de Protection des Personnes Sud Est V.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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